Comparison of the Time-Dependent Changes in Immediate Early Gene Labeling and Spine Density Following Abstinence From Contingent or Non-contingent Chocolate Pellet Delivery

Rationale: Incubation of craving is a phenomenon whereby responding for cues associated with a reward increases over extended periods of abstinence.Both contingent and non-contingent behavioral designs have been used to study the incubation of craving phenomenon with differing results.The present study directly compares behavioral and neural change

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Myocardial Impact of NHE1 Regulation by Sildenafil

The cardiac Na+/H+ exchanger (NHE1) is a membrane glycoprotein fundamental for proper cell functioning due its multiple housekeeping tasks, including regulation of intracellular pH, Na+ concentration, and cell volume.In the heart, hyperactivation of NHE1 has been linked to the development of different pathologies.Several studies in animal models th

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Type 1 diabetes mellitus: retrospect and prospect

Abstract Background Type 1 diabetes (T1D) is an autoimmune disease leading to destruction of insulin-producing pancreatic beta cells.Both genetic and environmental factors contribute to pathogenesis.The incidence of T1D is increasing worldwide, with significant geographic and ethnic variations.Patients present with yale law school colors symptoms o

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